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Kentaro Takayama Selected Research

Myostatin

3/2022Development of Myostatin Inhibitory d-Peptides to Enhance the Potency, Increasing Skeletal Muscle Mass in Mice.
1/2022Peptide Tool-Driven Functional Elucidation of Biomolecules Related to Endocrine System and Metabolism.
1/2021Development of functionalized peptides for efficient inhibition of myostatin by selective photooxygenation.
8/2020Peptide-2 from mouse myostatin precursor protein alleviates muscle wasting in cancer-associated cachexia.
8/2019Inactivation of myostatin by photo-oxygenation using catalyst-functionalized peptides.
1/2019[Medicinal Chemistry Focused on Mid-sized Peptides Derived from Biomolecules].
1/2019Design and synthesis of potent myostatin inhibitory cyclic peptides.
1/2017Structural Basis for the Effective Myostatin Inhibition of the Mouse Myostatin Prodomain-Derived Minimum Peptide.
4/2016Effect of N-Terminal Acylation on the Activity of Myostatin Inhibitory Peptides.
2/2015Identification of the minimum peptide from mouse myostatin prodomain for human myostatin inhibition.
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Kentaro Takayama Research Topics

Disease

5Muscular Dystrophies (Muscular Dystrophy)
01/2021 - 04/2016
5Neoplasms (Cancer)
08/2020 - 04/2010
5Obesity
01/2020 - 08/2014
3Muscular Atrophy (Muscle Atrophy)
03/2022 - 01/2015
3Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
10/2019 - 02/2015
3Glioma (Gliomas)
01/2014 - 09/2009
2Cachexia
08/2020 - 04/2016
2Inborn Genetic Diseases (Disease, Hereditary)
10/2017 - 10/2014
1Colitis
01/2022
1Muscular Diseases (Myopathy)
01/2022
1Phototoxic Dermatitis (Phototoxicity)
01/2021
1Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2020
1Muscle Weakness
01/2019
1Sarcopenia
04/2016
1Heart Failure
09/2015
1Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy)
01/2015
1Body Weight (Weight, Body)
08/2011
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
04/2010
1Urinary Bladder Neoplasms (Bladder Cancer)
04/2010

Drug/Important Bio-Agent (IBA)

11MyostatinIBA
03/2022 - 01/2015
9Peptides (Polypeptides)IBA
01/2021 - 09/2009
3neuromedin UIBA
01/2020 - 11/2016
3Nonsense Codon (Nonsense Mutation)IBA
10/2019 - 06/2015
3Pharmaceutical PreparationsIBA
01/2019 - 08/2014
2Proteins (Proteins, Gene)FDA Link
08/2020 - 04/2010
2Messenger RNA (mRNA)IBA
09/2015 - 08/2011
2Arginine (L-Arginine)FDA Link
04/2010 - 09/2009
1Dextran SulfateIBA
01/2022
1SolutionsIBA
01/2022
1Silicon Dioxide (Silica)FDA LinkGeneric
01/2020
1neuromedin U receptorIBA
01/2020
1BoronIBA
01/2020
1GadoliniumIBA
01/2020
1Cell-Penetrating PeptidesIBA
01/2020
1Amino AcidsFDA Link
10/2019
1EstersIBA
10/2017
1pyroglutamyl-histidyl-glycineIBA
11/2016
1ProdrugsIBA
07/2016
1Immunoglobulin G (IgG)IBA
07/2016
1NPI 2358IBA
07/2016
1Immunoconjugates (Immunoconjugate)IBA
07/2016
1FurinIBA
09/2015
1HydrazinesIBA
06/2015
1DystrophinIBA
06/2015
1Anti-Bacterial Agents (Antibiotics)IBA
06/2015
1negamycinIBA
06/2015
1CaveolinsIBA
01/2015
1polyarginineIBA
01/2014
1Small Interfering RNA (siRNA)IBA
08/2011
1AcidsIBA
04/2010
1Protein SIBA
04/2010

Therapy/Procedure

2Therapeutics
08/2011 - 04/2010
1Boron Neutron Capture Therapy
01/2020
1Intramuscular Injections
01/2015
1Drug Therapy (Chemotherapy)
12/2012